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Effect of N-acetylcysteine administration on 30-day mortality in critically Ill patients with septic shock caused by carbapenem-resistant klebsiella pneumoniae and acinetobacter baumannii: a retrospective case-control study

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Effects of Oral Supplementation With Plant Superoxide Dismutase Extract on Selected Redox Parameters and an Inflammatory Marker in a 2,000- m Rowing- Ergometer Test GliSODin, International Journal of Sport Nutrition and Exercise Metabolism, 2011, 124-134, Anna Skarpanska-Stejnborn, Lucja Pilaczynska-Szczesniak, Piotr Basta, Ewa Deskur-Smielecka, Donata Woitas-Slubowska, and Zdzislaw Adach SOD, a powerful antioxidant now available orally Due to the fragility of its molecular structure, non-protected SOD is inactivated in the digestive tract.Thanks to a coupling process with gliadin, a protein extracted from wheat,a SOD of vegetable origin (melon extract rich in SOD) is now available orally Abstract : Oxidative stress, the natural consequence of the oxygen metabolism, is normally controlled by antioxidant endogenous defense systems.When these prove to be insufficient, cellular lesions develop that result in ageing but also in some pathological processes.The powerful natural antioxidant enzyme superoxide dismutase (SOD) acts at the very source of the chain reaction resulting in reactive types of oxygen and therefore constitutes the first and one of the main links of the defense process against free radicals.Unfortunately, due to the fragility of its molecular structure, non-protected SOD is inactivated in the digestive tract.Thanks to a coupling process with gliadin, a protein extracted from wheat,a SOD of vegetable origin (melon extract rich in SOD) is now available orally.Several in vivo studies on animals as well as a clinical trial using healthy volonteers confirmed the preservation of the antioxidant activity of the SOD enzyme after oral administration;an action moreover combined with anti-inflammatory and immunomodulatory properties

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Table 3 Crystal structures of Ser-GSTs from plants