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Mosby Elsevier

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The major efficacy outcome measure was overall survival and additional efficacy outcome measures were time to disease progression, overall response rate, and response duration

Clinical trials measuring body composition found that fat mass reduction occurred without corresponding increases in lean tissue mass, confirming the absence of anabolic muscle-building effects

This not only drastically reduces the amount of ATP available for physical and cognitive tasks but also physically destabilizes the nervous system, leading to profound fatigue and neurological impairment