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Individual mutations of His-447 and Trp-448 to glycine resulted in the loss of flavin binding and enzyme function
Annals of Allergy, Asthma & Immunology, 95 (4), 336-343
[DOI] [PubMed] [Google Scholar] 37.Benor S, Russell GH, Silver M, Israel EJ, Yuan Q, Winter HS
Such inhibition significantly reduces the number of amyloid plaques in AD model mice and enhances their cognitive capabilities
These solidified aggregates are irreversible, and usually toxic
In hKOR, the S358, substituted by N in the rKOR, is the major phosphorylation site mediated by the GRK2 upon U50,488 exposure
