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Research on afamelanotide (melanotan 1) initially focused on Fitzpatrick Types I and II subjects with erythropoietic protoporphyria individuals whose photosensitivity made sun exposure clinically dangerous

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Histologically, dysplasic naevi have the following characteristic features (figure 13): Some pathologists use the term Superficial Atypical Melanocytic Proliferation of Unknown Significance or SAMPUS to describe dysplastic melanocytic lesions in which it is difficult to exclude melanoma in situ or radial growth phase invasive melanoma

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