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Researchers studying metabolic dysfunction in adipose tissue have identified NNMT as one of the most consistently upregulated enzymes in obese white fat, making it a high-confidence therapeutic target for metabolic intervention

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The results showed a statistically significant difference in fat loss between AOD-9604 and placebo, but the magnitude was modest

[DOI] [PubMed] [Google Scholar] 87.Heal DJ, Smith SL, Fisas A, Codony X, Buschmann H

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Quantitative measurement of selected metabolites in cultured cells The relative levels of selected metabolites (NA, SAM, SAH, NAD + ) regulated by cellular energy expenditure pathways associated with NNMT were simultaneously detected using LC/MS/MS and MRM ratios