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Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth

it also decreased ischemia-reperfusion injury, potentiated the vasodilator effects of nitroglycerin and angiotensin-converting enzyme inhibitors, and reduced myocardial oxidative stress

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Research Square 10.21203/rs.3.rs-3313783/v1

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CRISPR gene effect scores from Broad Achilles and Sanger SCORE combined screens (CRISPR_gene_effect.csv) and drug response data from the Cancer Therapeutics Response Portal (CTRP version 2.0) were downloaded from DepMap for AML cell lines