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IP administration produces rapid systemic exposure, whereas IN delivery enables sustained central access via olfactory pathways and bypass of the BBB [19]

JCR, 2015;197:48-57

Identification of COQ2 as a regulator of proliferation and lipid peroxidation through genome-scale CRISPRCas9 screening in myeloma cells

You may have a good shot guessing what atoms will be attracted if we mix, lets 2-bromobutane with a thiolate ion (RS), such as ethanethiolate: Yes, you are absolutely right, the negatively charged sulfur is going to attack the carbon with a partial positive charge

& Aquilina, J

178 This allows peripheral immune cells to infiltrate the central nervous system, contributing to neuroinflammation and accelerating neuronal damage
