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Structureactivity relationship for small molecule inhibitors of nicotinamide N -methyltransferase

The increased sensitivity of these two ASK1-dependent pathways in Nrf2-null fibroblasts is consistent with the mutant cells possessing heightened activity of ROS-sensitive signal transduction pathways

& Harper, J

doi: 10.1111/j.1541-4337.2005.tb00073.x

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The functions of NCOA4 are attributed to its structural design, comprising an N-terminal domain that facilitates protein-protein interactions, a central coactivator domain essential for its coactivation role and a C-terminal domain crucial for the autophagic breakdown of ferritin (7679)