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doi: 10.3389/fnut.2021.780205 Received 20 September 2021 Accepted 28 October 2021 Published 25 November 2021 Volume 8 - 2021 Edited by Andree Kurniawan, University of Pelita Harapan, Indonesia Reviewed by Chandrayani Simanjorang, State Polytechnic of Nusa Utara, Indonesia

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Hydrophobic forces or ionic interactions mediate the binding of membrane proteins to membrane lipids, forming lateral domains with certain functions such as environmental communication, adhesion, trafficking, and signaling

All three domains bind the HCV 3 UTR 17 : DI functions in both genome replication and virus assembly 18,19 , DII is exclusively involved in genome replication 20 and DIII plays a critical role in virion assembly 21