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In addition, it was previously revealed that knockdown of CHAC1 rescued the cysteine-starvation-induced reduction of glutathione levels and ferroptosis in human breast cancer cell lines (12)

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Interestingly, intranasal administration of epithalon peptide promoted c-Fos gene activation and subsequent increases in c-Fos only in the stress-induced rats, suggesting that epithalon contributes to pineal self-regulation under conditions of stress [17, 18]

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