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It increases the abundance of gut bacteria such as Lactobacillus reuteri and Blautia glucerasea, regulates the responses of target genes (e.g., Ugt1a5, Slc7a11, Pck1) and metabolites (e.g., 3Carboxy1hydroxypropylthiamine diphosphate, UDPDgalacturonic acid, Isopentenyl pyrophosphate), and modulates core networks of energy and substance metabolism, such as the citrate cycle and glycolysis/gluconeogenesis, inhibit uremic toxins, and improve RF [174]

Footnotes 1.^ References 1 da FonsecaDMHandTWHanS-JGernerMYGlatman ZaretskyAByrdALet al

Biochim Biophys Acta 1822:13631373

Mitochondria and Glutathione The other component is that poorly functioning mitochondria lead to a more free radical generation that leads to more inflammation