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The mRNA sequencing data generated and analyzed during the current study are available in the ArrayExpress repository, under accession number E-MTAB-15978

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21 Within the mitochondrial respiratory chain, complexes I and III are the main sites for superoxide radical productionmitochondrial DNA is especially vulnerable to oxidative damage due to its close location to ROS production and limited repair mechanisms

For this reason, its therapeutic potential concerns a series of diseases that link oxidative stress to its etiology and progression [3,4]

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Results: Our results indicate substantial variations in PR across the two regions