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Hepatic encephalopathy, as a consequence of advanced liver disease, is the major manifestation of the perturbed brain-gut microbiome axis

Rspondins bind both the E3 ubiquitin ligase and a member of Lgr family (Lgr4, Lgr5, and Lgr6) to form a ternary structure that abolishes the ubiquitination activity of the E3 ligase and thus augments Wnt activity by allowing surface accumulation of Fzd receptors
Fragment-Based Dynamic Combinatorial Chemistry for Identification of Selective -Glucosidase Inhibitors

MacFarlane LA, Todd DJ
