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Studies have indicated a significant decrease in steroid hormone synthesis in models with Beclin1 or Atg5 deletion, primarily attributed to a reduction in intracellular cholesterol supply [147, 148], suggesting that the autophagy-lysosome system may indirectly support steroidogenesis by preserving substrate availability [149]

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Acknowledgments CZ and MA deserve special recognition for their efforts in reviewing the text and providing direction throughout the project
