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A careful skeptic would say: the in-clinic procedure has solid evidence, the at-home extension is biologically plausible and consistent with the procedure, but the dataset is younger than the recommendation implies

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[DOI] [PubMed] [Google Scholar] 47.Kruckenberg KM, DiMartini AF, Rymer JA, Pasculle AW, Tamama K

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In addition to immune cells, the HRH2 gene is expressed in gastric parietal cells where the receptor plays a critical role in the regulation of gastric acid production in response to histamine