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Ethics declarations Ethics approval and consent to participate All procedures described herein were approved by the Institutional Review Board for the Protection of Human Subjects of Baylor University (Protocol # 7920244) and Research Ethical Review Committee of Kyowa Hakko Kirin Co., Ltd

As with any change to your routine, it is always a good idea to consult with your healthcare provider, especially if you are taking medication

Nat Commun 14(1):2533

Shannon, E., Conlon, M

Additionally, GSTM1 is a negative regulator of ASK1, a kinase involved in the apoptotic pathway [49]

Apoptotic bodies derived from the damaged hepatic cells can further activate Kupffer cells to secrete transforming growth factor beta 1, endothelial growth factor and platelet-derived growth factor, which can promote the transformation of activated hepatic stellate cells into myofibroblasts [19]