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Micronutrient selenium, which is considered a potent antioxidant, failed to reduce chronic chagasic cardiomyopathy in 66 male and female patients, according to a randomized, placebo-controlled, double-blinded clinical trial [96]

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In human and animal tissue, L-ergothioneine is concentrated in organs subject to significant oxidative stress: the liver, kidneys, heart, skin, lungs, spleen, small intestine, and blood (particularly in erythrocytes), as well as in ocular tissue and seminal plasma