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The determination of hypertension and awareness of antihypertensive medication at baseline were based on the principal investigators discretion and, as such, may represent a further limitation

doi: 10.1016/j.plaphy.2020.01.012 93 ShabbirZ.SardarA.ShabbirA.AbbasG.ShamshadS.KhalidS.et al

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When histamine binds to the H3 receptor, the molecular gate closes and prevents histamine from being released (bottom left)