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This GPT-catalyzed reaction plays an important role in the glucosealanine cycle, which is essential for supporting hepatic gluconeogenesis (96)

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Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver

It must be obtained externally by humans, where it is absorbed in the small intestine and stored in the liver

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