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The authors thank Shiliang Zhang and Rong Ye from the NIDA Confocal and Electron Microscopy Core for their expert technical assistance, Lauren Brick from NIDA media for figure preparation, Brandon Harvey for providing PC12 cells, and Michael Arends for proofreading the manuscript

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Indeed, we were able to confirm that dihexa can increase Ca 2+ -dependent cellular processes as endocytosis of E-cadherin is dependent on elevated intracellular Ca 2+ signaling following MET activation 38