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Capsules at room temperature is fine

[1] [2] Factors That Affect How Fast B12 Injections Work Multiple variables influence how quickly you will respond to B12 injection therapy, making it difficult to predict an exact timeline for any individual patient

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Notably, these macrocyclic peptides exhibit noncompetitive behavior with either SAM or NAM, suggesting that they may function as allosteric inhibitors targeting NNMT (Van Haren et al., 2021)