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[Google Scholar] David SL, Hsuan YG

DNA hypermethylation at gene promoters can result in transcriptional silencing

Manipulating CSE and ETHE1 levels in both directions, we found a consistent pattern in that the two enzymes mirrored each other: silencing CSE yielded the same effect (slower radical removal) as overexpressing ETHE1, and overexpressing CSE yielded the same effect (faster radical removal) as silencing ETHE1 (Fig

For the underlying biochemistry, see Is It a Peptide

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The mechanism of inactivation is thought to involve the irreversible modification of the catalytic cysteine (Cys302) via either carbamoylation or enone formation