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Intriguingly however, in glr1 cells, we observed almost no detectable NADP oxidation at all, except for a slight response of the NAPstar3 probe to the highest diamide concentration (5 mM) ( Figure 5C,E )

However, increased expression of this gene was observed in cells pretreated with 5 and 10 M CBD and exposed to 6-OHDA, indicating that the neuroprotective properties of CBD are mediated through the Nrf2 signaling pathway

10.1016/S0040-4039(01)81540-9

On the other hand, mice lacking Epac1 are protected against pressure overload or chronic catecholamine stress-induced cardiac dysfunction (Fujita et al., 2017), reinforcing the notion that rate- and pressure-induced cardiac failure may arise from separate cAMP pools

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