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It is true that the experiment and animal model of vitro provides us with valuable mechanism exploration and drug screening platform, but these results often face many uncertainties in the transformation of the complex human physiological environment

The study was approved by the Ethics Committee of the Institute of Neurosciences, Kolkata and registered at Clinical Trials Registry, India with the registration number CTRI/2017/02/007804

Therapeutic Prospective and Limitations Limiting side effects is of particular importance regarding angiotensin-based antihypertensive drugs given the documented problems of dry mouth, nausea and dizziness, muscle soreness, and diuresis that may occur with ACE inhibitors and ARBs

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In addition, these authors showed that acrolein was very effective in inhibiting the binding of NF-B1 (p50 subunit) to the IL-2 promoter using a chromatin immunoprecipitation assay