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Then, the pituitary (the VP) tells the workers (in this case, the end organs) what to do

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26 Indeed, expressing EGFR in Schwann cells in transgenic mice leads to the formation of neurofibroma-like lesions (although at a very low penetrance), whereas an inactivating EGFR mutation decreases its tumorigenic potential in a mouse model of MPNST

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This pattern is compatible with a sustained stimulatory action on growth hormone synthesis by pituitary cells and pulsatile release rather than a brief, desensitizing spike