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NAD+ is a coenzyme central to mitochondrial energy production and DNA repair

doi: 10.1038/srep46790 124

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TMAO is linked to several additional conditions besides atherosclerosis, such as HF, cancer, CKD, PH, and T2D [5, 71]

These findings demonstrated that TMAO exacerbates hepatic steatosis by altering bile acid metabolism and by suppressing FXR signaling in the liver (Tan et al., 2019)

et al.: MicrobiotaDependent Metabolite Trimethylamine NOxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA)