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Both FXR and TGR5 are highly expressed in the normal kidney tissues, but downregulated in DN, and the degree of decrease is associated with the inflammation and fibrosis (Wang X
When the levels of intracellular ROS surpass the counteracting capacity of intrinsic antioxidant defenses, oxidative stress arises and causes oxidative damage to biological molecules, leading to signaling disruption and eventually cell death [6]
AutophagyA key player in cellular and body metabolism
"Does poor sleep quality affect skin ageing?" Clinical and Experimental Dermatology, 2015
