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Protocolo profesional

ADAD is caused by rare and fully penetrant mutations in one of the three genes, APP and presenilin (PSEN) 1 and 2 , which follow a Mendelian autosomal dominant inheritance pattern

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Accordingly, we hypothesized that metabolic cholesterol abnormalities may be associated with free carnitine depletion during the fasting period, which warrants further investigation

Starvation, amino acid deprivation, or growth factor release, by removing the mTORC1 restraint, allows Ulk1 to promote autophagy

The clinical presentation includes oligomenorrhea or amenorrhea, hirsutism, and infertility (Sirmans & Pate, 2013)