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In future trials it will be important to keep track of comorbidities for clinical trial design, either for the purpose of post hoc subgroup analysis or a priori subgroup recruitment, since the neuroathophysiological mechanisms in IC/ BPS patients with different co-morbidities are likely to be different

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The analysis should be thoroughly documented and discussed with patients as part of the informed consent process

[Google Scholar] 88.Natarajan R, Ghosh S, Grogan W

This implies that while bridge node rankings remain relatively consistent, they should be interpreted with some caution