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non-conservative amino acid substitution refers to the amino acids substitution of an amino acid in one class with an amino acid from another class for example, substitution of an Ala, a class II residue, with a class III residue such as Asp, Asn, Glu, or Gin

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Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy

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