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However, efficient and targeted intra-articular gene delivery remains a considerable technical challenge, primarily due to the dense extracellular matrix (ECM) of cartilage, rapid clearance of joint fluid, and limited cellular uptake

Moreover, the authors also noted significant improvements in behavior and dopaminergic functions in PD rats, suggesting that intranasal delivery of OE-MSCs may be a promising and minimally invasive alternative in PD treatment [104]

These worms were cultured at 20 C for a 24-h fasting period

For many years, the medical treatment of RA has been basically based on the use of corticosteroids and traditional antirheumatic drugs (DMARDs), such as methotrexate (MTX) (Kerschbaumer et al., 2020)

Gestl SA, Green MD, Shearer DA, Frauenhoffer E, Tephly TR, Weisz J

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