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Residual beta-cell function more than glycemic control determines abnormalities of the insulin-like growth factor system in type 1 diabetes
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doi: 10.1038/278737a0

In addition, systemic adverse effects from colonic absorption of caffeine following a coffee enema are another issue that might be of concern to enema users or even mainstream physicians

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Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors
