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Collectively, these findings support the role of fecal microbiota influences and metabolic pathways (oxidative stress, inflammation) as underlying mechanisms for the beneficial effects of the MD in reproductive health, highlighting microbiota manipulation and metabolic interventions as promising avenues for further exploration (72)

320,321 Additionally, NOX2-generated ROS are necessary for LC3 recruitment to phagosomes, revealing an autophagy-dependent antibacterial activity of NOX2 in phagocytes

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1 KCs have a dynamic response depending on the type of stimulation and can secrete various sets of cytokines and chemokines, including Interleukin (IL)1, IL20, and tumor necrosis factoralpha (TNF) that can coordinate the skin inflammatory response whenever it is triggered