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The assembled DNA cassette was digested with SfiI and ligated upstream of C H 1-p3 into the SfiI-digested phagemid using T4 DNA ligase, yielding phagemids encoding Fabs linked to the N-terminus of a fragment of protein III (pIII: amino acids 230406) of filamentous phage M13 42

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In the trial, dose escalation occurred every 4 weeks from 0.25 mg at baseline to 2.4 mg at the end of the escalation period

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