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They include CAMP-response element binding protein (CREB), SP1 transcription factor (SP1), transcription factor AP-2 (AP2), proliferator-activated receptor alpha (PPAR), all activating GPX4 expression, while Krppel-like transcription factor 2 (KLF2) and CAMP-response element modulator (CREM), both repress its protein expression [7]

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TABLE 2 Antidepressant effects induced by phytochemicals based on neurotrophic factors

This pre-dispersion in the gastrointestinal tract can significantly enhance the dissolution and absorption of poorly soluble drugs like curcumin by presenting them in a finely dispersed, absorbable form (146)

Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo