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CRISPR/Cas9 gene editing: new hope for Alzheimer's disease therapeutics

Arteaga-Henrquez G, Gisbert L, Ramos-Quiroga JA

Molecular approaches include the generation of chimeric proteins such as an SOD1/3 chimera protein that contains the positively charged tail of SOD3 and has been shown to be more effective in protecting tissues than SOD1 (3), although this chimera was still retained in the kidney and was not optimal for therapeutic utility

Mild irritation is possible, especially when first starting use

Notably, patients with transferrin saturation (TSAT) levels below 20.1% benefited more from FCM therapy than those with TSAT levels above this threshold, even when ferritin levels were low [71]