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Furthermore, 8-oxo-dG DNA glycosylase (OGG1) recruited to these lesions interacts with TET1 that can trigger active DNA demethylation by BER (Zhou et al., 2016)

10.4049/jimmunol.2000212 J Immunol

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Similarly, in -syn preformed fibril (PFF) models, reduced or aberrantly localized AQP4 accelerated -syn aggregation, dopaminergic neuron loss, and behavioral deficits, in part through impaired glymphatic clearance of macromolecules (Braun et al., 2024

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Inhibition of this enzyme can lead to pellagra, which, in these cases, may present with cerebellar signs, myoclonus, and ataxia (55)