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Heldin CH, Miyazono K, ten Dijke P (1997) TGF-beta signalling from cell membrane to nucleus through SMAD proteins

[DOI] [PubMed] [Google Scholar] 117.Jarrett H., McNulty H., Hughes C.F., Pentieva K., Strain J.J., McCann A., McAnena L., Cunningham C., Molloy A.M., Flynn A., et al

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In co-culture models, astrocytes with ATP13A2 mutations show a reduced capacity to limit -syn accumulation in dopaminergic neurons, thereby enhancing the propagation of the protein [212]

Jun 29;129(7):141526

But it stressed that dose-response relationships were not established and that there is insufficient clinical safety information to characterize BPC-157's human safety profile with no studies administering it to humans by the proposed routes