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Abbreviations A : Amyloid beta ALS: Amyotrophic lateral sclerosis BH3: Bcl-2 homology domain-3 BSA: Bovine serum albumin BSO: Buthionine sulfoximine CGN: Cerebellar granule neuron DAPI: 4,6-Diamidino-2-phenylindole -GCL: -Glutamyl-cysteine ligase GSH: Glutathione GSH-MEE: Glutathione monoethylester GSS: Glutathione synthase HA14-1: 2-Amino-6-bromo- -cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester ICAL: Immunocal NAC: N-Acetyl cysteine NMDA: N-Methyl-D-aspartate Nrf2: Nuclear factor erythroid 2-related factor-2 ROS: Reactive oxygen species RNS: Reactive nitrogen species SOD1: Copper-zinc superoxide dismutase SNP: Sodium nitroprusside Sx c : System x c TDP-43: TAR DNA binding protein-43

There are potential risks from these treatments and they may not benefit the majority of patients with Barretts esophagus

In 2002, it was shown that symptomatic, unstable plaques demonstrated increased uptake of the glucose analogue [18F]-fluorodeoxyglucose compared to asymptomatic plaques, whereas healthy carotid arteries did not show glucose uptake (Rudd et al., 2002)

Therefore, the depletion of gliN or the overexpression of gtmA can alleviate the production of gliotoxin and promote the detoxification of gliotoxin, respectively

Osagie A

ND participated in study conceptualization, visualization, writing of the original draft, final draft review and editing