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Another characteristic of PD is oxidative DNA damage, which triggers PARP activation, leading to the depletion of NAD + levels 40,279,282284

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Shared and distinct mechanisms of fibrosis

These can be the upregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, altered NMDA receptor expression, altered dendritic morphology [167,168], and altered functioning of cholinergic (ACh-ergic) basal neurons, projecting to the cortex [169] by repeated exposure to amphetamine (amphetamine-induced sensitization)