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Resveratrol (RSV), a natural plant antitoxin with probiotic activity, was found to attenuate TMAO-induced AS by lowering TMAO levels and increasing hepatic bile acid synthesis by remodeling the gut microbiota ( / mice fed a HFD, the abundances of Firmicutes and Verrucomicrobia were changed and the expression of hepatic FMO3 and serum TMAO levels were markedly reduced (Shi et al., 2018)
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Testosterone is secreted to the plasma and also carried to Sertoli cells by androgen binding protein (ABP)
