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Determinants of bone microarchitecture and mechanical properties in obese men

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Desaturation and elongation of essential fatty acids The figure shows two vertical pathways of the metabolism of essential fatty acids, illustrating conversion to long-chain polyunsaturated fatty acids through desaturation (addition of a double bond) and elongation (addition of two carbon atoms) reactions: Omega-6 fatty acid pathway: At the top, linoleic acid (18:2n-6) is stepwise converted to 18:3n-6, then to 20:3n-6, then to 20:4n-6 (arachidonic acid), followed by conversion to 22:4n-6, 24:4n-6, 24:5n-6, and finally 22:5n-6

Polyunsaturated fatty acids are susceptible to lipid peroxidation caused by free radicals, which are produced by mitochondria because of the high metabolic rate of rapidly developing embryos [4]