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Because traditional FAK kinase domain inhibitors have limited effects on cancer cell apoptosis 12,13 but disruption of the FAT domain induces apoptosis 17,18,19 , we next tested lead FAT inhibitor 2012 in annexin V apoptosis assays

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Notably, a small cell lung carcinoma cell line, which expresses POMC and ACTH, possesses a hypomethylated POMC promoter, suggesting that ectopic ACTH secretion by tumors may be due to hypomethylation at a relatively early stage in carcinogenesis (41)

[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Wheatley C

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