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Description
LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models
Raghunathachar Sahana et al., 2017)
595 Transcriptome analyses suggest both gain and loss of functions in astrocytes in AD mouse models, with down-regulation of genes associated with neuronal support and upregulation of inflammation related genes
[DOI] [PubMed] [Google Scholar] 42.Powers SK, Jackson MJ
Microglia and macrophage role in neurodegeneration The etiology and mechanisms of neurodegeneration in MS remains an area of intense investigation
It was recently revealed that the inhibition of lysosomal function after traumatic spinal cord injury led to the significant accumulation of RIPK1, RIPK3, and MLKL in neurons, which was alleviated by the increased activation of autophagy-lysosome pathways 8
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