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MCP-1 is a chemo-attractant that recruits macrophages to the PC, thus decreasing levels of MCP-1 could reduce the secretion of pro-inflammatory cytokines and pain-inducing prostaglandins which are secreted by macrophages [110,111]

Multiple genome-wide association studies have found single nucleotide polymorphisms in TNFSF15 that are associated with an increased risk of CD and UC ( Based on the human genetic data and the promise of TL1A inhibition in non-clinical models, as well as the established efficacy of TNF inhibitors in IBD, Amgen designed AMG 966, a TNF/TL1A bi-specific immunoglobulin therapeutic candidate

10.1002/cne.21823 123 MasuM.TanabeY.TsuchidaK.ShigemotoR.NakanishiS

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