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The increased K m values of the T82A and T82S mutants suggest that T82 is involved in substrate binding 36

Michael L

Younger individuals with a significant family history or other predisposing factors may warrant earlier or more intensive screening protocols

5d), concordantly with the results observed using the GSH-synthesis inhibitor L-BSO (Supplementary Fig

However, further large-scale, well-designed clinical trials are needed to determine the appropriate dosages, treatment duration, and patient selection criteria

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