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Additionally, by inhibiting the TLR4/TRIF/type I IFN signaling pathway associated with ferroptosis, Fer-1 impedes neutrophil adhesion to coronary endothelial cells, thereby mitigating inflammation (178)

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In the field of prostate cancer (PC) treatment, Alcayaga-Miranda et al

& Wendisch, V

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In addition, the treatment of nicotinamide (NAM), a form of vitamin B3, suppressed the activity of sirtuin-1 (SIRT1), a regulator of cellular stress resistance, and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), a key transcriptional coactivator involved in mitochondrial biogenesis and energy metabolism