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For example, hyperglycemia increases the O-GlcNAc modification of calcium/calmodulin-dependent protein kinase II (CaMKII), which in turn leads to the autonomous activation of CaMKII ( 2+ leakage, improved cardiac contractility, and reduced arrhythmia events ( Figure 2 In summary, calcium plays an important role in cardiac dysfunction caused by ROS derived under the condition of hyperglycemia

In a study by Ray et al

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Protects liver and kidney against Chromium(VI)-Induced oxidative stress in mice

Monteleone M, Stanley AC, Chen KW, Brown DL, Bezbradica JS, von Pein JB, Holley CL, Boucher D, Shakespear MR, Kapetanovic R, et al

Ann Surg Oncol 22: 40024007