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Realistic timeline based on preclinical data and community reports.

Nose blowing did not predispose to acute bacterial paranasal sinusitis, and did correlate with a favorable treatment response

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Experimental design considerations include the importance of timing senolytic administration relative to senescence induction or disease progression, as the biological context affects both efficacy and interpretation of results

Bronchoalveolar lavage (BAL) was performed in 64 asthmatic children (severe asthma, n = 43)

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