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A rare but very serious side-effect is the allopurinol hypersensitivity syndrome, which can present with severe rash along with severe liver and blood cell abnormality

A thirty-second degree Mason, he was a member of the Anglo-Saxon Lodge
Due to its stability, its also widely used in fortified foods

Numerous case reports, preclinical and clinical trials, and systematic reviews have highlighted the potential benefit of SAMe in the treatment of depression, TRD, pain, fatigue, attention, and cognition
